![]() ![]() Kirkland JJ (1969) Controlled surface porosity supports for high-speed gas and liquid chromatography. Horvath C, Lipsky SR (1969) Column design in high pressure liquid chromatography. Hayes R, Ahmed A, Edge T, Zhang HF (2014) Core–shell particles: preparation, fundamentals and applications in high performance liquid chromatography. This work demonstrates that the fibrous core–shell silica particles could be used as an HPLC stationary phase with good performance and low back pressure, and that they have great potential for application to HPLC separation in the future. Furthermore, fibrous core–shell silica particles with an 80-nm shell were used for separating seven small molecules within 10 min and six proteins within 6 min. The results showed that the back pressure was as low as 8.5 MPa under the 1.0-mL min −1 flow velocity. ![]() ![]() The chromatographic properties of the particles were systematically studied in small-molecule and protein separation processes. The fibrous core–shell silica particles were further modified by n-octadecyltrichlorosilane and used as stationary-phase media in high-performance liquid chromatography (HPLC). The core–shell silica particles were composed of 3-µm non-pore silica cores and thin shells (50–100 nm), which have radial-like direct channels and a large pore size (19.89 nm). ![]() From drug discovery and pharmaceutical development to food safety and environmental analysis, Phenomenex chromatography solutions accelerate science and help researchers improve global health and well-being.In this study, fibrous core–shell silica particles were successfully synthesized via a one-step oil–water biphase stratification coating strategy. For more information, visit Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, clinical research, government and academic laboratories. Key applications that can greatly benefit from this dual selectivity include pesticide screening in food, testing of emerging environmental contaminants and drug analysis in pharmaceutical discovery, toxicology testing and clinical research. The new Kinetex Polar C18 is an ideal all-purpose phase for use with mixtures of multiple polar and nonpolar compounds or single-class methods with closely related compounds, such as impurities or metabolites. "This new selectivity greatly enhances polar/nonpolar retention compared to traditional alkyl phases and gives customers a versatile product with which they can start reversed phase method development." "We are pleased to extend the performance and sensitivity of our Kinetex Core-Shell Technology products to the challenges of retaining and analyzing polar compounds," comments Simon Lomas, strategic marketing manager for Phenomenex. This enables researchers to move back and forth between two different solid supports to better address method development needs and wants. With this new Kinetex particle, Phenomenex now offers the dual polar/nonpolar selectivity of the Polar C18 stationary phase in two particle types - Kinetex core-shell and Luna Omega thermally modified fully porous. On UHPLC systems, the 2.6 µm size provides comparable performance to fully porous sub-2 µm particles, but at much lower backpressure levels. Incorporating the key performance benefits of the Kinetex Core-Shell Technology, the 2.6 µm Polar C18 particle size provides high efficiency and performance on HPLC systems and potential increases in resolution, sensitivity and separation speed. This stationary phase combines C18 ligands with a polar-modified surface to enable superior retention of polar and nonpolar compounds while ensuring 100 percent aqueous stability. TORRANCE, CA -(Marketwired - May 12, 2017) - Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, introduces the Kinetex 2.6 µm Polar C18 - the ninth selectivity in the Kinetex core-shell family. ![]()
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